Sensitive and Specific Morphine Radioimmunoassay with Iodine Label: Pharmacokinetics of Morphine in Man after Intravenous Administration
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چکیده
منابع مشابه
Pharmacokinetics of morphine and its glucuronides following intravenous administration of morphine in patients undergoing continuous ambulatory peritoneal dialysis.
BACKGROUND Conjugation with glucuronic acid represents the major route of biotransformation of morphine. The glucuronides morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) are eliminated via the kidneys. Therefore, chronic renal failure should affect the disposition of M3G and M6G. Numerous patients undergoing long-term continuous ambulatory peritoneal dialysis (CAPD) require pain t...
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BACKGROUND An increased and prolonged duration of pain relief after morphine administration has been found in elderly patients. Whether this is due to alterations in pharmacokinetics, receptor binding profile or other factors remains unsolved. The aims were to elucidate the pharmacokinetics after intravenous administration of morphine and oxycodone in elderly patients older than 70 years. MET...
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Editor—We thank Dahan and Lotsch for their interest in our review and their valuable comments to the discussion about the role of morphine-6glucuronide (M6G), for the analgesic effect after morphine administration. Because morphine is used worldwide as the potent standard analgesic drug, with the formation of an even more potent metaboliteM6G, it is important to elucidate the relative contribut...
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ژورنال
عنوان ژورنال: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
سال: 1984
ISSN: 0004-5632,1758-1001
DOI: 10.1177/000456328402100415